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CD130 (Interleukin 6 Receptor beta, gp130, neutralizing, IL-6Rb, Interleukin-6 signal transducer)

CD130 (Interleukin 6 Receptor beta, gp130, neutralizing, IL-6Rb, Interleukin-6 signal transducer)

Cat no: C2464-05B

Supplier: United States Biological
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The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci?c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af?nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. CD126 is single chain type I transmembrane protein with Mr=130
Catalogue number: C2464-05B
Hosts: Rat
Applications: ELISA
Size: 500ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 1ml sterile PBS.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes mouse gp130. Does not crossreact with recombinant human gp130, recombinant mouse IL-6 or recombinant mouse IL-6R.

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