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CD134 (ACT35 Antigen, OX40, OX40L Receptor, TAX Transcriptionally-activated Glycoprotein 1 Receptor, TXGP1L, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4)

CD134 (ACT35 Antigen, OX40, OX40L Receptor, TAX Transcriptionally-activated Glycoprotein 1 Receptor, TXGP1L, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4)

Cat no: C2515-17

Supplier: United States Biological
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Tumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2515-17
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Gramaglia I, et al. Immunol 161:6510-6517, 1998. 2. Humphreys IR, et al. JEM 198:1237-1242, 2003
Additional info: Recognizes human OX40.

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