Home  >  Products  >  CD134 Ligand (CD134L, CD252, OX40 Ligand, OX40L, Txgp1, Tumor Necrosis Factor Ligand Superfamily Member 4, Tnfsf4) (PE)
CD134 Ligand (CD134L, CD252, OX40 Ligand, OX40L, Txgp1, Tumor Necrosis Factor Ligand Superfamily Member 4, Tnfsf4) (PE)

CD134 Ligand (CD134L, CD252, OX40 Ligand, OX40L, Txgp1, Tumor Necrosis Factor Ligand Superfamily Member 4, Tnfsf4) (PE)

Cat no: C2515-40R

Supplier: United States Biological
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CD252, otherwise known as OX40L or CD134L, a 22kD type II transmembrane glycoprotein and member of the TNF superfamily, expressed by antigen-presenting cells including activated dendritic cells and B cells, and also by vascular endothelium. The interaction of CD252 with its receptor OX40/CD134, acts as a co-stimulator of T cell activation, proliferation and both Th1 and Th2 cytokine production, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs). CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease. Applications: Suitable for use in Flow cytometry. Other applications have not been tested. Recommended Dilutions: Flow cytometry: Neat; Use 10ul of the suggested working dilution to label 1x10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4 degrees C. Reconstitute by adding sterile buffer or ddH2O. Aliquot and store at 4 degrees C. DO NOT FREEZE! Reconstituted product is stable for 12 months as an undiluted liquid. Dilute only prior to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2515-40R
Reactivities: Rat
Hosts: Mouse
Applications: Flow Cytometry
Size: 25 tests
Form: Supplied as a lyophilized powder from PBS, pH7.4, 1% BSA, 0.09% sodium azide. Labeled with PE. Reconstitute with 1ml sterile ddH2O.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affininty chromatography.
Alternative names: Tumor Necrosis Factor (Ligand) Superfamily, Member 4
References: 1. Satake, Y. et al. (2000) Characterization of rat OX40 ligand by monoclonal antibody. Biochem. Biophys. Res. Comm. 270: 1041-1048. 2. Yuan, X. et al. (2003) The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo. J. Immunol. 170: 2949
Additional info: Recognises rat CD252. Shown to block the co-stimulatory activity of CD252 on rat T cell proliferation.

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