Home  >  Products  >  CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor)
CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor)

CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor)

Cat no: C2548-41

Supplier: United States Biological
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A glycoprotein (256 amino acids) of 30kD, which exists as both a monomer and a 55kD dimer on the surface of activated T cells is identified as 4-1BB (also known as CD137). 4-1BB is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine. The cytoplasmic domain of 4
Catalogue number: C2548-41
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 250ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: General references: 1. Chu NR; DeBenedette MA; Stiernholm BJ; Barber BH; Watts TH. Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28-T cells. Journal of Immunology, 1997, 158:3081-9. 2. DeBenedette MA; Shahinian A; Mak TW; Watts TH. Costimulation of CD28-T lymphocytes by 4-1BB ligand. Journal of Immunol, 1997, 158:551-9. 3. Hurtado JC; Kim YJ; Kwon BS. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. Journal of Immunology, 1997, 158(6):2600-9. 4. Loo DT; Chalupny NJ; Bajorath J; Shuford WW; Mittler RS; Aruffo A. Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB. Journal of Biological Chemistry, 1997 Mar 7, 272(10):6448-56. 5. Garni-Wagner BA; Lee ZH; Kim YJ; Wilde C; Kang CY; Kwon BS. 4-1BB is expressed on CD45RAhiROhi transitional T cell in humans. Cellular Immunology, 1996, 169(1):91-8. 6. Gruss HJ; Duyster J; Herrmann F. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin
Additional info: Recognizes mouse CD137 (the mouse homologue of human 4-1BB protein).

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