CD137, Human IgG1 Fc Fusion Protein (FITC) (4-1BB, 4-1BB Ligand Receptor, CD137 Antigen, CDw137, ILA, T cell Antigen 4-1BB Homolog, T cell Antigen ILA, Tumor Necrosis Factor Receptor Superfamily Member 9, TNFRSF9)

Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2). CD137 appears to be important for T cell proliferation and survival (4). CD137 huIg fusion protein blocks binding of human CD137 to activated CEM human tumor cells.\n\nApplications:\nSuitable for use in ELISA and Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

C2548-39T

Size

50 tests

Applications

ELISA, FC

Form

Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride, 0.2% BSA, 0.04% sodium azide, 5% glycerol. Labeled with fluorescein isothiocyanate (FITC).

Purity

Purified by Protein A affinity chromatography.

References

1. M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227, 2. H.J. Gruss, and S.K. Dower, (1995) Blood 85: 3378-3404, 3. B.A. Garni-Wagner, et al, (1996) Cellular Immunol 169: 91-98, 4. H. Schwarz, et al, (1996) Blood 87: 2839-2845, 5. J. Langstein, et al, (1998) J Immunol 160: 2488-2494.

Alternative Names

FLJ43501, MGC2172