Home  >  Products  >  CD137 Ligand (CD137L, 4-1BB Ligand, 4-1BBL, 4-1BB-L, Tumor Necrosis Factor Ligand Superfamily Member 9, TNFSF9)
CD137 Ligand (CD137L, 4-1BB Ligand, 4-1BBL, 4-1BB-L, Tumor Necrosis Factor Ligand Superfamily Member 9, TNFSF9)

CD137 Ligand (CD137L, 4-1BB Ligand, 4-1BBL, 4-1BB-L, Tumor Necrosis Factor Ligand Superfamily Member 9, TNFSF9)

Cat no: C2548-55AX

Supplier: United States Biological
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Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells neuroblastoma cells (1), and some activated T cells. The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. This costimulus seems to be more effective for CD8+ effector T cells than for CD4+ helper T cells (3). The interaction can also effect a reverse signal, inducing monocyte activation (2), or T cell inactivation and programmed death (4) through CD137L. Applications: Suitable for use in ELISA, Western Blot and Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2548-55AX
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride. No preservative added.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
Alternative names: Tumor Necrosis Factor (Ligand) Superfamily, Member 9
References: 1. M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227, 2. J. Langstein, et al, (1998) J Immunol 160: 2488-2494, 3. V.Y. Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627, 4. H. Schwartz, et al, (1996) Blood 87: 2839, 5. G. Zhu, et al, (2001) J Immunol 167: 2671-6.
Additional info: Recognizes human CD137L. Binds to CD137L present on Raji and U-937 cells, and also binds to recombinant CD137L-muCD8 in EIA. Does not block the interaction between CD137 and CD137L.

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