CD137L CD8a, Fusion Protein (Preservative Free)

Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells and neuroblastoma cells (1). Binding of CD137 (4-1BB) to CD137L induces monocyte activation (2). Human CD137L-muCD8 binds to CD137 on human cells and is blocked by CD137-huIg fusion protein.\n\nFunctional Application: Human CD137L-muCD8 binds to CD137 and blocks binding of anti-CD137 monoclonal antibody.\n\nHuman CD137L-muCD8 Fusion Protein\n\nMolecular Structure: A soluble fusion protein consisting of the extracellular domain (184aa) of human CD137 Ligand fused to the extracellular domain (167aa) of murine CD8 alpha.\n\nTransfectant Cell Line: CHO\n\nApplications: \nSuitable for use in ELISA, Flow cytometry. Other applications not tested.\n\nRecommended Dilution\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.\n

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