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CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)

CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)

Cat no: C2265-49C

Supplier: United States Biological
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The CD14 molecule has been reported to be involved in the endotoxin mediated release of Tumor Necrosis Factor alpha by monocytic cells (see S.D. Wright et al.). Inhibits the endotoxin induced release of TNF by monocytes because it blocks the binding of LPS-LBP to monocytes. CD14 is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is present in low density on a subpopulation granulocytes and activated or transformed B-cells. The antibody reacts with both soluble and monocyte surface CD14. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2265-49C
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 15mM sodium azide, pH7.4.
P type: Mab
Isotype: IgG1
Purity: Purified from ascites by precipitation methods.
References: 1. Bazil, V., et al., 1986, Eur. J. Immunol. 16, 1583. 2. Bazil, V., et al., 1989, Mol. Immunol. 26, 657-662. 3. Leucocyte Typing III, ed. A. J. McMichael et al., Oxford Univ. Press, Oxford 1987; Workshop nr 253. See also contributions: M1.1 to M1.3, M1.6, M2.1, M2.2, M2.5, M4.5 others. 4. Knapp W., et al., 1989, Leukocyte Typing IV, Oxford Univ. Press 1989, See also contributions: M1.6, M3.2, M3.3, M15.1. 5. Leucocyte Typing V. Schlossman S. et al. 1995 Oxford University Press. 6. Sudan A. et al., 1994 Eur. J. Immunol. 24, 1779. 7. Leucocyte Typing VI. Kishimoto T. et al., 1997 Garland Publishing Inc.
Additional info: Recognizes human CD14 at ~53kD. Recognizes both soluble and monocyte surface CD14.

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