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CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)

CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)

Cat no: C2265-49D

Supplier: United States Biological
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The CD14 molecule has been reported to be involved in the endotoxin mediated release of Tumor Necrosis Factor alpha by monocytic cells (see S.D. Wright et al.). Inhibits the endotoxin induced release of TNF by monocytes because it blocks the binding of LPS-LBP to monocytes. CD14 is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is present in low density on a subpopulation granulocytes and activated or transformed B-cells. The antibody reacts with both soluble and monocyte surface CD14. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 5ul is required per 10e6 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2265-49D
Hosts: Mouse
Applications: Flow Cytometry
Size: 500ul
Form: Supplied as a liquid in BSA, 0.1 % sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Knapp, W. et al.. 1989. Leucocyte Typing IV. Oxford University Press Inc., New York. 2. Griffin, J.D.J.Ritz, L.M.Nadler, and S.F. Schlossman., 1981, J. Clin. Invest. 68, 932. 3. Todd, R.F.L.M. Nadler, and S.F. Schlossman, 1981, J. Immunol. 126, 1435. 4. Goyert, S.M.E.M. Ferrero, S.V. Semeritis, R.J. Winchester, J. Silber, and A.C. Mattison, 1986, J. Immunol. 37,3909. 5. Goyert, S.M. E.M.Ferrero, W.J.Rettig, A.K. Yenamamdra, F. Obata, and M.M. Le Beau, 1988, Science 239, 497. 6. Hazlot, A., S.Chen, E. Ferrero, M.G.Low, R. Silber, and S.M. Goyert, 1988, J. Immunol. 141, 547.
Additional info: Recognizes CD14. This molecule is a high affinity, GPI-linked receptor for lipopolysaccaride (LPS) and LPS binding protein (LBP). It is is expressed at high levels on peripheral blood monocytes. This receptor is also expressed on macrophages, dendritic cells and some Langerhans cells.

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