Home  >  Products  >  CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)
CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)

CD14 (CD14 Antigen, CD14 Molecule, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)

Cat no: C2265-49G

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Anti-CD14 antibody labels Kupffer cells in liver sinusoids. In lymphoid tissues, dendritic cells are distinctly stained. Most other normal tissues are negative. This antibody labels monocyte-macrophages and Langerhans cells in Langerhans cell histiocytosis. Tumor cells are positive in monocytic leukemia and true histiocytic lymphomas for CD14. Sinusoidal histiocytes express CD14 and CD 169, whereas most of the other monocyte-derived cells in reactive lymph node lack these markers. Anti-CD14 labels numerous diffuse large B-cell lymphomas and splenic marginal zone lymphoma but not in other B- cell lymphomas. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin, frozen): 1:50-1:200 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil, diffuse large B-cell lymphoma (DLBCL) Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2265-49G
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in PBS, pH7.4, protein base, sodium azide.
P type: Mab
Purity: Supernatant
References: 1. Marmey B, Boix C, et al., CD14 AND CD169 expression in lymph nodes and spleen: specific expansion of CD 14+CD169- monocyte-derived cells in diffuse large B-cell lymphomas. Human Pathol. 2006 Jan; 37(1):68-77. 2. Colovic N, Rajic Z, et al., Neutropenic enterocolitis in acute myeloid leukemia. Acta Chir Iugosl. 2004; 51(2):127-31. 3. Raife TJ, Laser DJ, et al., Expression of CD24 (BA-1) predicts monocytic lineage in acute myeloid leukemia. Am J Clin Pathol. 1994 Mar;101 (3):296-9. 4. Simiantonaki N, Kurzik-Dumke U, et al., Reduced expression of TLR4 is associated with the metastatic status of human colorectal cancer. Int J Mol Med. 2007 Jul; 20 (1):21-9. 5. Zhao D, Sun T, et al., Role of CD14 promoter polymorphisms in helicobacter pylori infection- related gastric carcinoma. Clin Cancer Res. 2007 Apr 15; 13 (8):2362-8. 6. Mason KD, Juneja SK, et al., The immunophenotype of acute myeloid leukemia: is there a relationship with prognosis? Blood Rev. 2006 Mar;20(2):71-82.
Additional info: Recognizes human CD14. Staining pattern: Cytoplasmic.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave