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Products CD14 (CD14 Antigen, Lipopolysaccharide Receptor, LPSR, Monocyte Differentiation Antigen 14, Myeloid Cell Specific Leucine Rich Glycoprotein)
| Catalogue number: | C2265-33U |
| Reactivities: | Human, Non-Human Primate |
| Hosts: | Mouse |
| Applications: | Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation |
| Size: | 100ug |
| Form: | Supplied as a liquid in PBS, 0.09% sodium azide. |
| P type: | Mab |
| Isotype: | IgG2a |
| Purity: | Purified by Protein G affinity chromatography. |
| Alternative names: | CD14 antigen, Lipopolysaccharide receptor, LPSR, Monocyte Differentiation Antigen 14, Myeloid cell specific leucine rich glycoprotein |
| References: | 1. Hogg, N. et al. (1984) Monoclonal antibodies specific for human monocytes, granulocytes and endothelium. Immunol. 53: 753-768, 2. Linch, D.C. et al. (1984) Monoclonal antibodies differentiation between monocyte and non-monocytic varients of AML. Blood. 63: 566-573, 3. Hogg, N. and Horton, M.A. (1987) Myeloid antigens: new and previously defined clusters in Leucocyte Typing III White Cell differentiation antigens. Edited by McMichael, A.J., Beverley, P.C.L., Cobbold, S., Crumpton, M.J., Gilks, W., Gotch, F.M., Hogg, N., Horton, M., Ling, N., Mackenna, I.C.M., Mason, D.Y., Milstein, G., Speghelhalter., D. and Waldmann, H. et al, 4. Jonker, M. et al. (1989) Reactivity of mAb specific for human CD markers with Rhesus monkey leucocytes. Leucocyte Typing IV. Oxford University Press p 1058-1063, 5. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49 (2): 97-110. 6. Angel, C.E. et al. (2006) Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J. Immunol. 176: 5730-5734.7. Bournazos, S. et al. (2008) Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arterioscler Thromb Vasc Biol. 28: 1491-8 8. Hovden, A.O. et al. (2011) Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol. 12:2. 9. Hsu, T.L. et al. (2002) Modulation of dendritic cell differentiation and maturation by decoy receptor 3. J Immunol. 168: 4846-53. 10. Karlsson, H. et al. (2002) Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora. Infect Immun. 70: 6688-96. |
| Additional info: | Recognizes human CD14. Recognizes a monocyte surface antigen of 55kD found chiefly on monocytes. Gives positive staining reactions with monocytic cells, the interfollicular tissue macrophages seen under the capsule, and dendritic reticulum cells in tonsil tissue sections. Skin Langerhans cells are always negative. Also reacts with Kupffer cells and sinus lining cells on the liver. Species Crossreactivity: Cynomolgus monkey, Rhesus monkey, fish, trout. |
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