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CD14 (Monocyte Differentiation Antigen CD14, Myeloid Cell-specific Leucine-rich Glycoprotein)

CD14 (Monocyte Differentiation Antigen CD14, Myeloid Cell-specific Leucine-rich Glycoprotein)

Cat no: C2265-55C

Supplier: United States Biological
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CD14 is a glycophosphatidylinositol-linked protein, which is part of the LPS receptor complex. CD14 binds lipopolysaccharide (LPS) and as such, acts as a pattern recognition receptor (PRR). CD14 has also been suggested to mediate phagocytosis of bacteria an apoptotic cells. CD14 is involved in the endotoxin mediated release of Tumor Necrosis Factor-alpha by monocytic cells. CD14 is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is present in low density on a subpopulation of granulocytes and activated or transformed B-cells. Applications: Suitable for use in Flow Cytometry, Immunofluorescence with cells and Functional Studies. Other applications not tested. Recommended Dilution: Flow Cytometry: 1ug/ml Immunofluorescence/ Immunocytochemistry: 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: RAW-cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2265-55C
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Hajishengallis, G et al; Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect Immun 2006, 74: 5658
Additional info: Recognizes the mouse monocyte marker CD14, a 53kD glycoprotein.

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