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CD14 (Monocyte Differentiation Antigen CD14, Myeloid Cell-specific Leucine-rich Glycoprotein)

CD14 (Monocyte Differentiation Antigen CD14, Myeloid Cell-specific Leucine-rich Glycoprotein)

Cat no: C2265-55W

Supplier: United States Biological
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CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens and in the upregulation of adhesion molecules and cytokines expression in monocytes and neutrophils. Applications: Suitable for use in Immunofluorescence, Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2265-55W
Reactivities: Human, Bovine, Canine, Porcine, Sheep
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. McMichael, A., et al. 1987. Leucocyte Typing III. Oxford University Press. New York. 2. Knapp, W., et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York. 3. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 4. Power, C. P., et al. 2004. J. Immunol. 173:5229. 5. Williams, K.C., et al. 2001. J. Exp. Med. 193:905. 6. Iwamoto, S., et al. 2007. J. Immunol. 179:1449. (FC) 7. Santer, DM., et al. 2010. J. Immunol. 485:4739. 8. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 9. Stocks, S., et al. 1990. Biochem. J. 268:275. 10. Wright, S., et al. 1990. Science 249:1434.
Additional info: Recognizes human CD14. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, bovine, sheep, porcine, canine.

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