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Products CD141 (TM, Thrombomodulin, Fetomodulin)
| Catalogue number: | C2548-75D |
| Reactivities: | Human |
| Hosts: | Rat |
| Applications: | Flow Cytometry, Western Blot |
| Size: | 100ug |
| Form: | Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. |
| P type: | Mab |
| Isotype: | IgG2a |
| Purity: | Purified by Protein G affinity chromatography. |
| Alternative names: | Thrombomodulin |
| References: | 1. Domotor, E et al; Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 2003, 101: 4797 2. Sturn, D et al; Expression and function of the endothelial protein C receptor in human neutrophils. Blood 2003, 102: 1499 3. Esmon, C. et al; The protein C pathway. Chest 2003, 124: 26S 4. Wouwer, M van de et al; Novel functions of thrombomodulin in inflammation. Crit Care Med 2004, 5: 254. |
| Additional info: | Recognizes thrombomodulin (a C-type lectin also known as CD141), a complex molecule located on the endothelium and a key feature in the protein C pathway. RTM98 reacts with the EGF6 domain, thereby inhibiting the biological activity of thrombomodulin. |
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