CD147, Recombinant, Human (BSG, Basigin, 5F7, Collagenase Stimulatory Factor, Extracellular Matrix Metalloproteinase Inducer, EMMPRIN, Leukocyte Activation Antigen M6, OK Blood Group Antigen, Tumor Cell-derived Collagenase Stimulatory Factor, TCSF, UNQ650

EMMPRIN (extracellular matrix metalloproteinase inducer) also called CD147 is a 58kD protein with two immunoglobulin domains that was originally purified from the plasma membrane of the human LX-1 lung carcinoma cell line. EMMPRIN has been localized on the outer surface of tumor cells, where it interacts with fibroblasts to stimulate the expression of matrix metalloproteinases (MMPs). EMMPRIN expression has been observed in normal oral mucosa epithelium, kidney tissue, neoplastic oral squamous cell carcinoma, lung carcinoma, urinary bladder cancer, in situ ductal breast carcinoma and in the peripheral granulocytes of rheumatoid arthritis patients. High level of EMMPRIN expression has been shown to correlate with both MMP expression and cancer invasive potentia.\n\nSource: \nRecombinant corresponding to human CD147 expressed in E.coli.\n\nMolecular Weight:\n~84kD\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

136875

Size

2ug

Form

Supplied as a liquid in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% glycerol.

Purity

Purified

References

1. [CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 May;23(5):426-8. 2. [Expression of CD147 and MMP-2 in human gliomas and its correlations with prognosis] Sichuan Da Xue Xue Bao Yi Xue Ban 2007 Jun;38(3):396-9. 3. Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples. World J Gastroenterol 2007 Jun 7;13(21):2913-7. 4. HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res 2007 Jun;5(6):605-14. 5. Roles of CD147 on T lymphocytes activation and MMP-9 secretion in systemic lupus erythematosus. J Cell Mol Med 2007 Mar-Apr;11(2):339-48. 6. Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membra ne in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 2007 May 1;67(9):4182-9.