Home  >  Products  >  CD148 (Receptor-type Tyrosine-protein Phosphatase eta, Protein-tyrosine Phosphatase eta, R-PTP-eta, Density-enhanced Phosphatase 1, DEP-1, HPTP eta, Protein-tyrosine Phosphatase Receptor Type J, R-PTP-J, PTPRJ, DEP1)
CD148 (Receptor-type Tyrosine-protein Phosphatase eta, Protein-tyrosine Phosphatase eta, R-PTP-eta, Density-enhanced Phosphatase 1, DEP-1, HPTP eta, Protein-tyrosine Phosphatase Receptor Type J, R-PTP-J, PTPRJ, DEP1)

CD148 (Receptor-type Tyrosine-protein Phosphatase eta, Protein-tyrosine Phosphatase eta, R-PTP-eta, Density-enhanced Phosphatase 1, DEP-1, HPTP eta, Protein-tyrosine Phosphatase Receptor Type J, R-PTP-J, PTPRJ, DEP1)

Cat no: C2548-81K

Supplier: United States Biological
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CD148, a receptor-like protein tyrosine phosphatase also known as human protein tyrosine phosphatase-eta (HPTP-eta) or density-enhanced protein tyrosine phosphatase-1 (DEP-1), is involved in signal transduction in leukocytes and is thought to contribute to mechanisms of cellular differentiation. In lymphoid organs, CD148 was found to be widely expressed on B and T cells, granulocytes, macrophages, certain dendritic cells as well as mature thymocytes. The cellular level of CD148 was increased after in vitro activation of peripheral blood leukocytes. CD148 as a leukocyte activation marker and may be involved in the regulation of T cell activation. Leukocytes expressing CD148 are significantly upregulated in inflamed tissues and that a subset of these cells co-expresses the activation marker CD25. In non-lymphoid tissues, CD148 was found to be present on many epithelial cell types with glandular and/or endocrine differentiation as well as on fibrocytes, melanocytes and Schwann cells. Among non-hematopoietic cells, CD148 is expressed by characteristic types of epithelial and non-epithelial cells. Downregulation of CD148 might promote dedifferentiation and autonomous growth of such cells in malignant tumors. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)1ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2548-81K
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Tangye S.G. 1998. J. Immunol.161:3249. 2. Tangye S.G. 1998. J. Immunol.161:3803. 3. Tangye S.G. 1998. J. Exp. Med. 188:1691. 4. Autschbach F. 1999. Tissue Antigens. 54:485. 5. Lin J. and Weiss A. 2003. J. Cell Biol. 162:673.
Additional info: Recognizes human CD148.

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