The CD151 molecule, also known as PETA-3/SFA, is a member of the family of tetraspanin transmembrane proteins. Tetraspanins are characterized by one small and one large extracellular loop, a small cytoplasmic loop and short amino and carboxy-terminal domains. They act as linkers between extracellular integrin alpha chain domains and intracellular signalling molecules. They are involved in a wide range of cellular processes such as cell adhesion, motility, activation, proliferation, differentiation and cancer. The CD151 molecule has been reported to be expressed in basal cells of epidermis, epithelial cells, skeletal, smooth and cardiac muscle cells, schwann cells, platelets, megakaryocytes and endothelial cells. In the small intestine, CD151 is reported to be expressed by crypt and villous enterocytes but is not detectable on the brush border.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry: Paraffin
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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