CD152 Antibody

Cat no: 251548

Supplier: ABBIOTEC

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Description
Additional Information

CD152 antigen (Cytoto, Xenopus/Amphibian,ic T-lymphocyte protein 4, CTLA-4) binds to B7-1 (CD80 antigen) and B7-2 (CD86 antigen), resulting in T-cell activation. Genetic variation in CD152 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. SLE affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Mutations in CD152 have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, thyroid-associated orbitopathy, and other autoimmune diseases.

Catalogue number:	251548
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P16410
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD152.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	CTLA-4; CD152; Cytoto, Xenopus/Amphibian,ic T-lymphocyte-associated antigen 4; Cytoto, Xenopus/Amphibian,ic T-lymphocyte protein 4; CTLA4