Home  >  Products  >  CD152, Fab Monomer (CD152 Antigen, CELIAC3, Cytotoxic T-lymphocyte Protein 4, Cytotoxic T-lymphocyte-associated Antigen 4, CTLA4, CTLA-4, GRD4, GSE, ICOS, IDDM12)
CD152, Fab Monomer (CD152 Antigen, CELIAC3, Cytotoxic T-lymphocyte Protein 4, Cytotoxic T-lymphocyte-associated Antigen 4, CTLA4, CTLA-4, GRD4, GSE, ICOS, IDDM12)

CD152, Fab Monomer (CD152 Antigen, CELIAC3, Cytotoxic T-lymphocyte Protein 4, Cytotoxic T-lymphocyte-associated Antigen 4, CTLA4, CTLA-4, GRD4, GSE, ICOS, IDDM12)

Cat no: C2548-83G5

Supplier: United States Biological
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Human CD152 (CTLA-4) is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. Applications: Suitable for use in ELISA, Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Fixed cells or tissues Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2548-83G5
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein A affinity chromatography.
Alternative names: Cytotoxic T-lymphocyte-associated Protein 4
References: 1. T.L. Walunas, et al, (1994) Immu nity 1:405-413, 2. N.J. Karandikar, et al, (1996) J Exp Med 184: 783-788, 3. A. Kitani, et al, (2000) J Immunol 165: 691-702, 4. Y. Zheng, D.M. Sansom, et al, (2004), 5. S Vendetti, M.T. DeMagistris, et al. (2008) Immunology Letters 115(1):59-69.
Additional info: Recognizes human CD152 (CTLA-4) expressed on activated T cells. Binds to CD152 present on activated T cells, and blocks binding of recombinant CD152 (CTLA-4) fusion protein to CD80/CD86 receptors.

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