Home  >  Products  >  CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5)
CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5)

CD154 (CD40 Ligand, CD40-L, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5)

Cat no: C2548-84T

Supplier: United States Biological
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Human CD154 (CD40 Ligand) is a member of the tumor necrosis factor (TNF) family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10-1:50 10ul labels 10e6 cells in 100ul. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2548-84T
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 200ug
Form: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
Alternative names: CD40 Antigen Ligand, Hyper IgM Syndrome, T-B cell Activating Molecule
References: 1. Hermann, P. et al. (1993). Expression of a 32kD ligand for the CD40 antigen on activated human T lymphocytes. Eur. J. Immunol. 23:961-964. 2. Lane, P. et al. (1992). Activated human T cells express a ligand for the human B cell associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur. J. Immunol. 22:2573-2578. 3. Kroszek, R.A. et al. (1994). Defective expression of CD40 ligand on T cells causes "X-linked Immunodeficiency with hyper-IgM (HIGML) Immunol. Rev. 138:39-59.
Additional info: Recognizes human CD154 at ~32kD.

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