Home  >  Products  >  CD154 (CD40 Ligand, CD40L, CD40-L, hCD40L, CD40LG, gp39, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen Gp39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5)
CD154 (CD40 Ligand, CD40L, CD40-L, hCD40L, CD40LG, gp39, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen Gp39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5)

CD154 (CD40 Ligand, CD40L, CD40-L, hCD40L, CD40LG, gp39, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen Gp39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNFSF5)

Cat no: C2548-84W5

Supplier: United States Biological
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Human CD154 (CD40 Ligand) is a member of the tumor necrosis factor (TNF) family and is expressed on the surface of activated T cells. It can undergo proteolytic cleavage into an immunologically active soluble form. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function (1). Increased levels of CD154 has been associated with autoimmune disorders including SLE, CLL and eosinophilic fasciitis (5,9,10,11). CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells, macrophages and activated platelets indicating a role for the CD40-CD154 immunoregulatory signaling in artherosclerosis and cardiovascular disorders (7,12,13). Applications: Suitable for use in ELISA, Western Blot, Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2548-84W5
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride. No preservative added.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. D. Gray, et al, (1994) Seminars in Immunol 6: 303-310, 2. F. Pietravalle, et al, (1996) J Biol Chemistry 271: 5965-5967, 3. R.J. Noelle, (1996) Immunity 4: 415-419, 4. A. Desai-Mehta, et al, (1996) J Clin Invest 97: 2063-2073, 5. I.S. Grewal and R.A. Flavell, (1996) Immunol Today 17: 410-414, 6. F. Mach, et al, (1997) Proc Natl Acad Sci USA 94:1931-1936, 7. F. Pietraville, et al, (1996) Eur J. Immunol 26:725-728, 8. U.G. Wagner, C. Weyland, et al, (1998) J Immunol 161: 6390-6397.
Additional info: Recognizes human CD154. Immunoprecipitates a CD154 (gp39) molecule of ~39kD. Blocks MLR, sgp39 induced human B cell proliferation and T cell dependent B cell differentiation.

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