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CD16 (Low Affinity Immunoglobulin gamma Fc Region Receptor III, IgG Fc Receptor III, Fc-gamma RIII, FcRIII, Fcgr3)

CD16 (Low Affinity Immunoglobulin gamma Fc Region Receptor III, IgG Fc Receptor III, Fc-gamma RIII, FcRIII, Fcgr3)

Cat no: C2267-32M

Supplier: United States Biological
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CD16 is known as low affinity IgG receptor III (FcgRIII). It is expressed as two distinct (CD16a and CD16b) forms. CD16a (FcgRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcgRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. It is over 95% homologous to CD16a in extracellular domain and is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex that functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). The 3G8 antibody blocks neutrophil phagocytosis and stimulates NK cell proliferation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 20ul per million cells in 100ul volume Immunohistochemistry: acetone-fixed frozen tissue Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2267-32M
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 3. Edberg, J., et al. 1997. J. Immunol. 159:3849. 4. Hoshino, S., et al. 1991. Blood 78:3232. 5. Tamm, A., et al. 1996. Immunol. 157:1576. 6. Da Silva, D.M. et al. 2001. Int. Immunol. 13:633. 7. Holl, V., et al. 2004. J. Immunol. 173:6274. 8. Hober, D., et al. 2002. J. Gen. Virol. 83:2169. 9. Brainard, DM., et al. 2009. J. Virol. 83:7305.< 10. Smed-S
Additional info: Recognizes human CD16. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, marmoset.

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