CD160 (also BY55) is a 27kD member of Ig Superfamily of molecules. It is expressed on select hematopoietic cell types, including CD56dim CD16+cytotoxic NK cells, CD8+ CD28effector
T cells, gd T cells, and restricted CD4+ T cells. It is a receptor for HLAC molecules, and its engagement induces CD160+ NK cells to both secrete IFNg plus TNFg and initiate a cytotoxic program. Human CD160 was originally identified as a 155aa proprotein (aa27181). It contains a 132aa mature region (aa27159) and a Cterminal prosegment that is cleaved to create a GPI linkage. The mature region possesses one Vtype Ig like domain (aa27122). CD160 is found as a soluble, disulfidelinked 80kD multimer (likely trimer) that is generated by proteolysis of the
GPIlinked form. This 80kD form, plus others, are highly resistant to reduction. There is also a 100110kD multimeric transmembrane (TM) form that is associated with activated NK cells. It contains a 55aa substitution for Gly180Leu181, and shows a 20aa TM segment between aa 163182. The TM form appears to have a splice variant that lacks aa25133. Over aa27159,
human CD160 shares only 62% aa sequence identity with mouse CD160. Human CD160.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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