CD161 (CLEC5B, Killer Cell Lectin-like Receptor Subfamily B Member 1, KLRB1, MGC138614, NKR, NKR-P1, NKRP1A, NKR-P1A)

Cat no: C2548-88H

Supplier: United States Biological

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Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or D161, is classified as a type II membrane protein because it has an external C terminus.[1] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Human CD161 is a homodimeric disulfide-linked type II membrane bound glycoprotein found mainly on NK cells. CD161 has been implicated in the regulation of NK cell mediated cytotoxicity. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:50-1:100; 10ul labels 10e6 cells in 100ul Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Hybridoma: X63-Ag8-653 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2548-88H
Reactivities:	Rat
Hosts:	Mouse
Applications:	Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size:	100ug
Form:	Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type:	Mab
Isotype:	IgG1
Purity:	Purified by Protein G affinity chromatography.
References:	1. Sedgwick, J.D. et al. (1998) Central Nervous system microglial cell activation and proliferation follows direct interation with Tissue-infiltrating T Cell Blasts. J. Immunol. 160: 5320-5330. 2. Tliba, O. et al. (2002) Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats. Vet. Res. 33(3):327-32. 3. Schwartzkopff, J. et al. (2010) NK cell depletion delays congeal allograft rejection in baby rats. Mol. Vis. 16: 1928-1935. 4. Lyons, A. et al. (2011) Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain. J Neuroinflammation. 8: 27. 5. Ali, S. et al. (2005) Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model. Cancer Res. 65: 7194-204. 6. Banerjee, S. et al. (2003) Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats. Br J Ophthalmol. 87: 1515-22. 7. Latta, M. et al. (2007) CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis. Immunology. 121: 555-64.
Additional info:	Recognizes rat CD161.

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CD161 (CLEC5B, Killer Cell Lectin-like Receptor Subfamily B Member 1, KLRB1, MGC138614, NKR, NKR-P1, NKRP1A, NKR-P1A)

Cat no: C2548-88H

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