Home  >  Products  >  CD178, Low Endotoxin (Apt1lg1, CD95 Ligand, CD95L, CD95-L, Fas Antigen Ligand, Fas Ligand, Faslg, Fasl, Fas-L, gld, Tumor Necrosis Factor Ligand Superfamily Member 6, Tnfsf6)
CD178, Low Endotoxin (Apt1lg1, CD95 Ligand, CD95L, CD95-L, Fas Antigen Ligand, Fas Ligand, Faslg, Fasl, Fas-L, gld, Tumor Necrosis Factor Ligand Superfamily Member 6, Tnfsf6)

CD178, Low Endotoxin (Apt1lg1, CD95 Ligand, CD95L, CD95-L, Fas Antigen Ligand, Fas Ligand, Faslg, Fasl, Fas-L, gld, Tumor Necrosis Factor Ligand Superfamily Member 6, Tnfsf6)

Cat no: C2548-91P3

Supplier: United States Biological
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CD178, otherwise known as Fas Ligand/ CD95L, is a 40kD type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis. C2442-32M1 is reported to block CD178/CD95 induced apoptosis. Applications: Suitable for use in Flow Cytometry and Functional Assays. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:25-1:200; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Endotoxin: (same/less than)1EU/ug Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2548-91P3
Reactivities: Mouse, Rat
Applications: Flow Cytometry
Size: 500ug
Form: Supplied as a liquid in PBS, pH7.4. No preservative added. No stabilizing proteins added.
P type: Mab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
Alternative names: Fas Ligand (TNF Superfamily, Member 6), Generalized Lymphoproliferative Disease, TNF Superfamily Member 6
References: 1. Trinite, B. et al. (2000) A subset of cytolytic dendritic cells in rat. J. Immunol. 165: 4202-4208. 2. Watanabe, T. et al. (2002) Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 Ligand and secreting IL-4 in the liver. J. Immunol. 168: 2188-2199. 3. Kayagaki, N. et al. (1997) Polymorphism of murine Fas ligand that affects the biological activity. P.N.A.S. 94: 3914-3919.
Additional info: Recognizes mouse CD95L at ~40kD. Species Crossreactivity: rat.

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