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CD18 (Leukocyte Function Associated Antigen, LFA-1 beta2)

CD18 (Leukocyte Function Associated Antigen, LFA-1 beta2)

Cat no: C2269-08G

Supplier: United States Biological
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CD18, a 95kD protein, is a beta2-integrin subunit expressed mainly on leukocytes. It is a member of Integrin family and consists of an extracellular domain, a transmembrane region and a cytoplasmic tail. It is non-covalently attached to CD11a, CD11b or CD11c to form LFA-1, Mac-1 and p150, 95 beta2-integrins respectively. It is essential for the binding of alpha sub-units to specific ligands and is crucial for proper functioning of individual integrins. CD18 also has a role in cell adhesion and migration. CD18 deficiency in humans reduces inflammatory cell recruitment of leukocytes. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:25-1:75 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2269-08G
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Hildreth et al. Eur J Immunol 13: 202, 1983. 2. McMichael eds. Leukocyte Typing III. Oxford, New York, Tokyo: Oxford University Press, 1987. 3. Law et.al EMBO J. 1987 April; 6(4): 915
Additional info: Recognizes human CD18, LFA-1, beta Chains.

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