Home  >  Products  >  CD180 (CD180 Antigen, Lymphocyte Antigen 64, Radioprotective 105kD Protein, LY64, RP105) (Biotin)
CD180 (CD180 Antigen, Lymphocyte Antigen 64, Radioprotective 105kD Protein, LY64, RP105) (Biotin)

CD180 (CD180 Antigen, Lymphocyte Antigen 64, Radioprotective 105kD Protein, LY64, RP105) (Biotin)

Cat no: C2588-07B

Supplier: United States Biological
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RP105 is a type 1 transmembrane protein of 105kD with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2588-07B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Conjugates: Biotin
Size: 50ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. Labeled with Biotin.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Miura Y, et al; RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood 1998, 92: 2815. 2. Tsuneyoshi, N et al; The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J Immunol 2005, 174: 340.
Additional info: Recognizes human CD180.

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