Home  >  Products  >  CD180 (CD180 antigen precursor, LY64, Ly78, Lymphocyte Antigen 64, MGC126233, MGC126234, Radioprotective 105kD Protein, RP105)
CD180 (CD180 antigen precursor, LY64, Ly78, Lymphocyte Antigen 64, MGC126233, MGC126234, Radioprotective 105kD Protein, RP105)

CD180 (CD180 antigen precursor, LY64, Ly78, Lymphocyte Antigen 64, MGC126233, MGC126234, Radioprotective 105kD Protein, RP105)

Cat no: C2548-93J

Supplier: United States Biological
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CD180 is a type 1 transmembrane protein of 105kD with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. CD180 is similar to Drosophila Toll in the extracellular LLRs. CD180 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that CD180 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of CD180 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing CD180 as a potent regulator of B-cell activation. In this context it is important to note that CD180 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of CD180. Applications: Suitable for use in Immunoprecipitation, Flow Cytometry, Immunohistochemistry and in vitro functional studies. Other applications not tested. Recommended Dilution: Immunoprecipitation: 1:50 Flow Cytometry: 1:50 Immunohistochemistry (frozen): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2548-93J
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: CD180
References: 1. Miura Y, et al; CD180 is associated with MD-1 and transmits an activation signal in human B cells. Blood 1998, 92: 2815 2. Tsuneyoshi, N et al; The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J Immunol 2005, 174: 340
Additional info: Recognizes human CD180 (RP105).

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