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CD180 (RP105, Radioprotective 105, Ly78) (FITC)

CD180 (RP105, Radioprotective 105, Ly78) (FITC)

Cat no: C2548-93G

Supplier: United States Biological
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Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105kD with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: C2548-93G
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
Alternative names: RP105, CD180, lymophocyte antigen 65
References: 1. Miyake, K et al; Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol 1998, 161: 1348 2. Nagai, Y et al; Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood 2002, 99: 1699
Additional info: Recognizes mouse RP 105.

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