CD1a (Langerhans Cells)

Cat no: C2251-54C

Supplier: United States Biological

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Description
Additional Information

he CD1 locus encodes a family of major histocompatibility complex (MHC) antigen-like glycoproteins which associate with beta 2-microglobulin and are expressed on immature thymocytes, Langerhans cells, and dendritic cells (1). Among five CD1 genes (a, b, c, d, e), CD1a, -b, and -c, have been clustered with monoclonal antibodies and may function as nonclassical antigen-presenting molecules (2). CD1a mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains (3). CD1a molecules are expressed on dendritic cells during certain maturational phases coincident with the functions of antigen capture and processing (4). On thymocytes, CD1a forms noncovalent complexes with CD1b and CD1c, and a disulfide-linked heterodimer with CD8 (5). Applications: Suitable for use in Immunocytochemistry, Western Blotting. Other applications not tested. Recommended Dilution: Western Blot: 1:5,000-1:200,000 Immunocytochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	C2251-54C
Reactivities:	Human, Mouse
Hosts:	Rabbit
Applications:	Immunocytochemistry, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
References:	1. S P Balk, et al. PNAS 86(1): 252-256, 1989. 2. A Woolfson, et al. PNAS 91(14): 6683-6687, 1994 3. Zajonc DM, et al. Immunity. 22(2):209-19, 2005. 4. Coventry B. J., et al. Anticancer research 19(4B): 3183-3187, 1999. 5. Aruffo A, et al. J Immunol. 143(5):1723-30, 1989
Additional info:	Recognizes human CD1a.

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CD1a (Langerhans Cells)

Cat no: C2251-54C

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