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CD2 (T-cell Surface Antigen CD2, Erythrocyte Receptor, LFA-2, LFA-3 Receptor, Rosette Receptor, T-cell Surface Antigen T11/Leu-5, SRBC)

CD2 (T-cell Surface Antigen CD2, Erythrocyte Receptor, LFA-2, LFA-3 Receptor, Rosette Receptor, T-cell Surface Antigen T11/Leu-5, SRBC)

Cat no: C2253-12U

Supplier: United States Biological
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CD2 is a 50kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. The major ligand for CD2 is CD58 (also known as LFA-3). CD2 has also been reported to bind CD48, CD59, and CD15. CD2 plays a critical role in alternative T cell activation, T cell signaling, and cell-cell adhesion. Applications: Suitable for use in Flow Cytometry, Blocking of T Cell Activation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.25ug/10e5 cells in 100ul Immunohistochemistry: acetone-fixed, frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2253-12U
Reactivities: Human, Mollusc, Porcine, Sheep
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 0.2% BSA.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Knapp, W., et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Aversa, G., et al. 1987. Transplant. Proc. 19:277. 3. Zaretsky, AG., et al. 2009. J. Exp Med. 4. Perona-Wright, G., et al. 2010. Nat. Immunol. 11:520. (FC). 5. Thummler, K., et al. 2010. J. Leukoc Biol. 6. Kap, Y., et al. 2009. J. Histochem. Cytochem. 57:1159. (IHC). 7. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC). 8. Bell, G., et al. 1995. J. Immunol. 155:2805. 9. Bierer, B., et al. 1989. Annu. Rev. Immunol. 7:579. 10. Moingeon, P., et al. 1989. Immunol. Rev. 111:111.
Additional info: Recognizes human CD2. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, pigtailed macaque, sheep, porcine.

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