Home  >  Products  >  CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)
CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)

CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)

Cat no: C2270-05R

Supplier: United States Biological
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CD20, a non-glycosylated cell-surface protein expressed exclusively on B lymphocytes, is one of a family of 4-pass transmembrane molecules. CD20 (B-cell Pan) is a 33kD transmembrane protein that reacts with a membrane antigen present in B-cells. It consists of four transmembrane regions and a cytoplasmic N- and C-terminus. The CD20 antigen is expressed in most B-cells that are present in peripheral blood and lymphoid tissue. CD20 could be detected on lineage B cells from the pre-B cell stage to the mature B lymphocytes. The CD20 antigen is found on more than 90% of B-cell lymphomas. CD20-initiated intracellular signals involve tyrosine kinase activation, and CD20 is tightly associated with both serine and tyrosine kinases. CD20 is a surface protein with the capacity to initiate intracellular signals and modify cell growth and differentiation The analysis of CD20-associated molecules has revealed that CD20 is associated with the Src family tyrosine kinases p56/53, p56, and p59 and with 75/80kD proteins phosphorylated in vivo on tyrosine residues. Applications: Suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunoprecipitation: 3-5ug/extract from 10e7 cells Immunohistochemistry: 1:100 Optimal dilutions to be determined by the researcher. Positive Control: BJAB WCL and tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2270-05R
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Andersson, P. et al. Expert Rev Mol Med 6, 1 (2004). 2. Bayerl. et al. Am J Clin Pathol 122, 858 (2004). 3. Gaipa. et al. Leukemia 11 (2004). 4. Deans, J. et al. J Biol Chem 270, 22632 (1995). 5. Clark, E. et al. J Immunol 138, 720 (1987). 6. Smeland. et al. J Immunol 138, 3179 (1987).
Additional info: Recognizes human CD20.

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