Home  >  Products  >  CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)
CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)

CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)

Cat no: C2270-16A

Supplier: United States Biological
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Members of MS4A protein family are characterized by the presence of 4 highly conserved transmembrane domains. CD20, a 35-37kD human B-cell specific tetraspan membrane protein, is a unique member of this family. CD20 plays a major role in the initiation of intracellular signaling and regulating B-cell growth and differentiation. It complexes with BCR and regulates Calcium ion entry, thereby regulating B-cell signaling and activation. Antibodies such as Rituximab directed against CD20 are being extensively used for the treatment of B-cell lymphomas. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:100-1:750 Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Human T cell line Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2270-16A
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Supernatant
References: 1. Ishii et al. Clin Exp Immunol 58: 183, 1984. 2. Mason et al. Am J Pathol 136: 1215, 1990. 3. Cartun et al. Am J Pathol 129: 415,1987. 4. Li et.al J. Biol. Chem., 279 (19), 19893-19901 (May 7, 2004).
Additional info: Recognizes human CD20.

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