Home  >  Products  >  CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)
CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)

CD20 (B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1)

Cat no: C2270-16V

Supplier: United States Biological
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CD20 is a 33-37 kD four transmembrane spanning protein also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated in activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn), and exists in a complex with MHC class I and II, CD53, CD81, and CD82. The mAb 1412 recognizes the cytoplasmic domain of the CD20 molecule. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2270-16V
Reactivities: Human, Mollusc
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Schlossman, S., et al. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Knapp, W., et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. 3. McMichael, A., et al. Eds. 1987. Leucocyte Typing III, Oxford University Press. New York. 4. Polyak , M. J., et al. 2002. Blood 99:3256. 5. Mack, C.L., et al. 2004. Pediatr. Res. 56:79. 6. Hultin, L., et al. 1993. Cytometry 14:196. 7. Tedder, T., et al. 1994. Immunol. Today 15:450.
Additional info: Recognizes human CD20. Species Crossreactivity: chimpanzee, baboon, cynomolgus, rhesus, pigtailed macaque.

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