Home  >  Products  >  CD20 (B1, B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, CVID5, Leukocyte Surface Antigen Leu-16, LEU-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1, MS4A2, MGC3969, S7)
CD20 (B1, B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, CVID5, Leukocyte Surface Antigen Leu-16, LEU-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1, MS4A2, MGC3969, S7)

CD20 (B1, B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, CVID5, Leukocyte Surface Antigen Leu-16, LEU-16, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1, MS4A2, MGC3969, S7)

Cat no: C2270-08E

Supplier: United States Biological
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Members of MS4A protein family are characterized by the presence of 4 highly conserved transmembrane domains. CD20, a 35-37kD Human B-cell specific tetraspan membrane protein, is a unique member of this family. CD20 plays a major role in the initiation of intracellular signaling and regulating B-cell growth and differentiation. It complexes with BCR and regulates Calcium ion entry, thereby regulating B-cell signaling and activation. Antibodies such as Rituximab directed against CD20 are being extensively used for the treatment of B-cell lymphomas. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:25-1:50 Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Cellular Localization: Cell membrane Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2270-08E
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Membrane-spanning 4-domains, Subfamily A, Member 1
References: 1. Coles et al. Modern Pathol 1: 274, 1988. 2. Davey et al. Am J Pathol 129: 54, 1987. 3. Linder et al. 1: 29: 1988. 4. Li et.al J. Biol. Chem., 279 (19), 19893-19901 (May 7, 2004).
Additional info: Recognizes human CD20.

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