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Products CD20 (CD20 Antigen, B1, B-lymphocyte Cell-surface Antigen B1, Bp35, CD20 Receptor, LEU-16, MGC3969, Membrane-spanning 4-domains Subfamily A Member 1, MS4A1, MS4A2, S7) (PE)
| Catalogue number: | C2270-01Z1 |
| Reactivities: | Human |
| Hosts: | Mouse |
| Applications: | ELISA, Flow Cytometry |
| Size: | 2ml |
| Form: | Supplied as a liquid in PBS, pH 7.2. |
| P type: | Mab |
| Isotype: | IgG2a |
| Purity: | Mouse ascites |
| References: | *Leucocyte Typing VII. Mason D. et al. (Eds.), Oxford University Press (2002). *Polyak MJ, Deans JP.: Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Blood. 2002 May 1;99(9):3256-62. *Chan HT, Hughes D, French RR, Tutt AL, Walshe CA, Teeling JL, Glennie MJ, Cragg MS: CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts. Cancer Res. 2003 Sep 1;63(17):5480-9. *Teeling JL, Mackus WJ, Wiegman LJ, van den Brakel JH, Beers SA, French RR, van Meerten T, Ebeling S, Vink T, Slootstra JW, Parren PW, Glennie MJ, van de Winkel JG.: The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol. 2006 Jul 1;177(1):362-71. |
| Additional info: | Reacts with CD20 (Bp35), a 33-37kD non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes. Species Crossreactivity: Human. |
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