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CD21 (CR2, C3d Receptor, EBV Receptor)

CD21 (CR2, C3d Receptor, EBV Receptor)

Cat no: C2272-54E

Supplier: United States Biological
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CD21 is a single-pass type 2 transmembrane protein that serves as the complement receptor for C3d and the Epstein-Barr virus. It is a member of a family of C3b/C4b binding proteins that regulate complement activation, comprise tandemly repeated 60-75 amino acid sequences, and whose genes map to band q32 on chromosome 1 (1). CD21 interacts with the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein to regulate their functions. Phosphorylation of CD21 inhibits its interaction with the nuclear p120 ribonucleoprotein (2). Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:20 Western Blot: 1:1000-1:10,000 Immunoprecipitation: 1:50 Immunohistochemistry (Paraffin): 1:250-1:500 Immunocytochemistry: 1:250-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2272-54E
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Weis, J.J., et al., J. Exp. Med. 167(3): 1047-1066 (1988). 2. Barel, M., et al., Mol. Immunol. 32(6): 389-397 (1995).
Additional info: Recognizes human CD21 at ~155kD. Species Crossreactivity: mouse (by Western Blot only).

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