Home  >  Products  >  CD22 (B Cell Receptor CD22, B-lymphocyte Cell Adhesion Molecule, BL-CAM, T-cell Surface Antigen Leu-14, MGC130020, Sialic Acid Binding Immunoglobulin-like Lectin 2, Sialic Acid-binding Ig-like Lectin 2, SIGLEC 2, SIGLEC-2, SIGLEC2)
CD22 (B Cell Receptor CD22, B-lymphocyte Cell Adhesion Molecule, BL-CAM, T-cell Surface Antigen Leu-14, MGC130020, Sialic Acid Binding Immunoglobulin-like Lectin 2, Sialic Acid-binding Ig-like Lectin 2, SIGLEC 2, SIGLEC-2, SIGLEC2)

CD22 (B Cell Receptor CD22, B-lymphocyte Cell Adhesion Molecule, BL-CAM, T-cell Surface Antigen Leu-14, MGC130020, Sialic Acid Binding Immunoglobulin-like Lectin 2, Sialic Acid-binding Ig-like Lectin 2, SIGLEC 2, SIGLEC-2, SIGLEC2)

Cat no: C2272-98H

Supplier: United States Biological
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CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. The human CD22 gene is expressed specifically in B lymphocytes and likely has an important function in cell-cell interactions. The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. CD22 is located within the band region q13.1 of chromosome 19. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-1ug/ml detects CD22 in cells and tissues. Immunohistochemistry (FFPE/frozen): 0.5-1ug/ml detects CD22 in formalin fixed paraffin tissues and formalin or acetone fixed tissues. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2272-98H
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human CD22. Species Crossreactivity: mouse, rat.

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