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CD22, phosphorylated (Tyr762)

CD22, phosphorylated (Tyr762)

Cat no: C2272-89C

Supplier: United States Biological
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CD22, a negative regulator of B cell signaling, belongs to the sialoadhesin family of receptors that preferentially binds to a2-6-linked sialic acid on glycoproteins (1-2). CD22 is known to interact with the B cell antigen receptor (BCR) (3) and the tyrosine phosphatase SHP1. Tyrosine phosphorylation of CD22 leads to the recruitment of multiple intracellular Src homology 2 (SH2) domain-containing effector molecules, including phospholipase C {g} and Syk, which are important for triggering Ca2+ influx, as well as PI 3-kinase and Grb2 (4-5). Applications: Suitable for use in Western Blotting, Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2272-89C
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Wilson GL, et al. J. Immun. (150):5013-5024, 1993. 2. Nitschke LH, et al. Scand. J. Immunol. (53):227, 2001. 3. Tedder TF, et al. Annu. Rev. Immunol. (15):481, 1997. 4. Yohannan JJ, et al. J. Biol. Chem. (274):18769, 1999. 5. Otipoby KL, et al, J. Biol. Chem. (276):44315, 20
Additional info: Recgognizes human CD22 phosphorylated on Tyrosine 762.

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