Home  >  Products  >  CD226 (CD226 Antigen, Adhesion Glycoprotein, DNAX Accessory Molecule 1, DNAM1, DNAM-1, Platelet and T cell Activation Antigen 1, PTA1, TLiSA1) (FITC)
CD226 (CD226 Antigen, Adhesion Glycoprotein, DNAX Accessory Molecule 1, DNAM1, DNAM-1, Platelet and T cell Activation Antigen 1, PTA1, TLiSA1) (FITC)

CD226 (CD226 Antigen, Adhesion Glycoprotein, DNAX Accessory Molecule 1, DNAM1, DNAM-1, Platelet and T cell Activation Antigen 1, PTA1, TLiSA1) (FITC)

Cat no: C2548-97G3

Supplier: United States Biological
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CD226 is a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:10-1:20; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Catalogue number: C2548-97G3
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity. 4: 573 - 581. 2. Shibuya, A. et al. (1998) Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX Accessory molecule-1 receptor. J. Immunol. 161. 1671 - 1676. 3. Kojima, H. et al. (2003) CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J. Biol. Chem. 278 (38): 36748 - 36753. 4. Manes, T.D. and Pober, J.S. (2011) Identification of Endothelial Cell Junctional Proteins and Lymphocyte Receptors Involved in Transendothelial Migration of Human Effector Memory CD4+ T Cells. J Immunol. 186: 1763-8. 5. Ardolino, M. et al. (2011) DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction. Blood. 117: 4778-86. 6. Soriani, A. et al. (2009) ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood. 113: 3503-11. 7. Matusali, G. et al. (2012) The Human Immunodeficiency Virus Type 1 Nef and Vpu Proteins Downregulate the Natural Killer Cell-Activating Ligand PVR. J Virol. 86: 4496-504.
Additional info: Recognizes human CD226. Reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.

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