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CD24, Recombinant, Mouse:Fc (M1/69-J11D Heat Stable Antigen, Nectadrin, Lymphocyte Antigen 52, X62 Heat Stable Antigen (HSA))

CD24, Recombinant, Mouse:Fc (M1/69-J11D Heat Stable Antigen, Nectadrin, Lymphocyte Antigen 52, X62 Heat Stable Antigen (HSA))

Cat no: 044654

Supplier: United States Biological
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CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. Widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns). Sequence: Mouse CD24 (aa 27-52) is fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 6 months after receipt when stored at -20 degrees C.
Catalogue number: 044654
Size: 50ug
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Purity: >90% (SDS-PAGE)
Alternative names: M1/69-J11D Heat Stable Antigen, Nectadrin, Lymphocyte Antigen 52, X62 Heat Stable Antigen (HSA)

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