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CD244 (CD244 Molecule, Natural Killer Cell Receptor, 2B4)

CD244 (CD244 Molecule, Natural Killer Cell Receptor, 2B4)

Cat no: C2548-99N

Supplier: United States Biological
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This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:64,000 Western Blot: 1-3ug/ml ~75kD band observed in Human Natural Killer (NK) cell lysates after immunoprecipitation with mouse monoclonal antibody C1.7 coupled to Protein G agarose (calculated MW of 41.1kD according to NP_057466.1). We do note that CD244 is a glycoprotein which makes a higher size band to be expected. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2548-99N
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: natural killer cell receptor 2B4, NK cell activation inducing ligand NAIL, CD244 natural killer cell receptor 2B4, SLAMF4, Nmrk, NKR2B4, NAIL, 2B4, CD244 molecule, natural killer cell receptor 2B4, CD244 Official
References: 1. Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips JH Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol. 1999 Jun 15;162(12):6981-5.
Additional info: Recognizes human CD244.

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