Home  >  Products  >  CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA) (APC)
CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA) (APC)

CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA) (APC)

Cat no: C2275-82G1

Supplier: United States Biological
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CD25 is a 55kD transmembrane glycoprotein consisting of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. It is expressed during early stages of thymocytes development and in activated CD4+ memory T-lymphocytes. CD25 heterodimerizes with IL2R-beta and IL-2R gamma and forms the tripartite high affinity IL-2 receptor complex. It increases the specificity and affinity of IL-2 receptor complex for IL-2 ligand and is necessary for receptor clustering required for augmentation of IL-2 signaling. Mutations in CD25 result in severe immunodeficiency. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry (Cell Surface): 0.1-0.5ug/1x10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Catalogue number: C2275-82G1
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. Labeled with Allophycocyanin (APC).
P type: Mab
Isotype: IgG1,l
Purity: Purified by Protein G affinity chromatography.
References: 1. Leonard et al. Nature 300: 267, 1982. 2. Leonard et al. Proc Natl Acad Sci USA 80: 6957, 1983. 3. Erber et al. Am J Clin Pathol 89: 645, 1988. 4. Sharfe et.al PNAS 94; 3168-3171 (April 1997) 5. Vamosi et.al PNAS 101 (30); 11082-11087 (July 27, 2004)
Additional info: Recognizes mouse CD25.

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