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CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA)

CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA)

Cat no: C2275-82H

Supplier: United States Biological
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CD25 is a 55kD transmembrane glycoprotein consisting of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. It is expressed during early stages of thymocytes development and in activated CD4+ memory T-lymphocytes. CD25 heterodimerizes with IL2R-beta and IL-2R gamma and forms the tripartite high affinity IL-2 receptor complex. It increases the specificity and affinity of IL-2 receptor complex for IL-2 ligand and is necessary for receptor clustering required for augmentation of IL-2 signaling. Mutations in CD25 result in severe immunodeficiency. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:75 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2275-82H
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Waldmann J. Biol. Chem., 266 (5); 2681-2684 (1991 Feb 15) 2. Sharfe et.al PNAS 94; 3168-3171 (April 1997) 3. Vamosi et.al PNAS 101 (30); 11082-11087 (July 27, 2004)
Additional info: Recognizes human CD25.

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