Home  >  Products  >  CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA) (PE)
CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA) (PE)

CD25 (Interleukin-2 Receptor Subunit alpha, IL-2 Receptor Subunit alpha, L-2-RA, IL-2R Subunit alpha, IL2-RA, TAC Antigen, p55, IL2RA) (PE)

Cat no: C2275-82G3

Supplier: United States Biological
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CD25 is a 55KD transmembrane glycoprotein consisting of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. It is expressed during early stages of thymocytes development and in activated CD4+ memory T-lymphocytes. CD25 heterodimerizes with IL2R-beta and IL-2R gamma and forms the tripartite high affinity IL-2 receptor complex. It increases the specificity and affinity of IL-2 receptor complex for IL-2 ligand and is necessary for receptor clustering required for augmentation of IL-2 signaling. Mutations in CD25 result in severe immunodeficiency. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.05-0.1ug/1x10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: C2275-82G3
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% sodium azide. Labeled with R-Phycoerythrin (PE).
P type: Mab
Isotype: IgG1,l
Purity: Purified by Protein G affinity chromatography.
References: 1. Leonard et al. Nature 300: 267, 1982. 2. Leonard et al. Proc Natl Acad Sci USA 80: 6957, 1983. 3. Erber et al. Am J Clin Pathol 89: 645, 1988. 4. Sharfe et.al PNAS 94; 3168-3171 (April 1997) 5. Vamosi et.al PNAS 101 (30); 11082-11087 (July 27, 2004)
Additional info: Recognizes mouse CD25.

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