CD254 Antibody

Cat no: 251263

Supplier: ABBIOTEC

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Description
Additional Information

Tumor necrosis factor ligand superfamily member 11 (CD254) is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. CD254 augments the ability of dendritic cells to stimulate naive T-cell proliferation. CD254 is an important regulator of interactions between T-cells and dendritic cells and plays a role in the regulation of the T-cell-dependent immune response. CD254 also plays a role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Defects in CD254 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2), also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone.

Catalogue number:	251263
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	O14788
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD254.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	RANKL; Osteoprotegerin ligand; OPGL; Tumor necrosis factor ligand superfamily 11; Receptor activator of nuclear factor kappa B ligand; TNF-related activation-induced cytokine; TRANCE; Osteoclast differentiation factor; ODF; CD254