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CD26 (Dipeptidyl Peptidase IV, DPP IV)

CD26 (Dipeptidyl Peptidase IV, DPP IV)

Cat no: C2277-06M

Supplier: United States Biological
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Dipeptidyl peptidase IV (DPP IV) is widely distributed in a number of mammalian tissues and is suggested to play an important role in various kinds of biological processes. DPP IV (CD26) is a serine-type protease that removes the amino-terminal dipeptide from peptide substrate provided that the penultimate amino acid residue is proline or alanine. DPP IV plays an important role in the reclamation of peptide nitrogen from larger peptides. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry, and Immunoassay. Other applications not tested. Recommended Dilution: Western Blot: 1:10 Immunohistochemistry (frozen): 1:10 Immunoprecipitation: 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2277-06M
Reactivities: Rat
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: DPVV IV, CD26
References: 1. Mizuno, M et al; Monoclonal antibodies indentifying antigens on distinct domains of rat hepatocytes. Liver 1987, 7: 251 2. Hyodo, I et al; Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma. Liver 1993, 13: 80 3. Ariyoshi, M et al; Identification of a target antigen recognized by mouse monoclonal antibody to the bile canalicular surface of rat hepatocytes with a random phage display library. Acta Med Okayama 2002, 56: 187
Additional info: Recognizes DPP IV present on the apical surface of epithelial cells in the pancreas, small intestine, colon, and bile duct. Furthermore antibody 5E8 reacts with DPP IV on the laminar portions of the proximal renal tubule cells, and, weakly, on the glomeruli.

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