CD27, Mouse IgG2a Fc Fusion Protein (CD27 Antigen, CD27 Molecule, CD27L Receptor, MGC20393, S152, T-cell Activation Antigen CD27, T14, Tp55, Tumor Necrosis Factor Receptor Superfamily Member 7, TNFRSF7)

Human CD27 is a lymphocyte specific member of the tumor necrosis factor receptor family (TNFRSF7) and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells. The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily (TNFSF7). The CD27-CD70 interaction plays an important role in T cell activation.\n\nReactivity:\nRecombinant soluble CD27-muIg binds to cell surface CD70 on Raji cells in FACS, and is reactive with recombinant CD70-muCD8 and CD27.\n\nApplications:\nSuitable for use in ELISA and Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2379-12E

Size

25ug

Applications

ELISA, FC

Form

Supplied as a liquid in 50mM sodium phosphate, pH 7.5, 100mM potassium chloride, 150mM sodium chloride. No preservative added.

Purity

Purified by Protein A affinity chromatography.

References

1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 350-352, 2. K. Agematsu, et al.(1994) J Immunol 153(4): 1421-1429, 3. R.Q. Hintzen, et al, (1994) Immunol Today 15: 307-311, 4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 356-360, 435-437, 5. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.