Home  >  Products  >  CD274, Recombinant, Human, aa19-238, His-Tag (Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7 Homolog 1, B7-H1, B7H1, PDCD1L1, PDCD1LG1, PDL1)
CD274, Recombinant, Human, aa19-238, His-Tag (Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7 Homolog 1, B7-H1, B7H1, PDCD1L1, PDCD1LG1, PDL1)

CD274, Recombinant, Human, aa19-238, His-Tag (Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7 Homolog 1, B7-H1, B7H1, PDCD1L1, PDCD1LG1, PDL1)

Cat no: 045413

Supplier: United States Biological
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CD274, also known as programmed cell death 1 ligand 1(PDCD1L1), is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. This protein interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Source: Recombinant corresponding to aa19-238 from human CD274, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~27.9kD (245aa) confirmed by MALDI-TOF AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMFTVTV PKDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNER Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 045413
Size: 20ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 10% glycerol.
Purity: ~90% (SDS-PAGE)
References: 1. Dong H., et al. (1999) Nat. Med. 5:1365-1369. 2. Freeman G.J., et al. (2000) J. Exp. Med. 192:1027-1034.

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