Home  >  Products  >  CD276 (4Ig-B7-H3, B7 Homolog 3, B7-H3, B7H3, CD276 Antigen, CD276 Molecule, Costimulatory Molecule)
CD276 (4Ig-B7-H3, B7 Homolog 3, B7-H3, B7H3, CD276 Antigen, CD276 Molecule, Costimulatory Molecule)

CD276 (4Ig-B7-H3, B7 Homolog 3, B7-H3, B7H3, CD276 Antigen, CD276 Molecule, Costimulatory Molecule)

Cat no: C2549-27B

Supplier: United States Biological
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CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:10-1:100; 10ul labels 10e6 cells in 100ul Immunohistochemistry (Frozen): 1:100 Optimal dilutions to be determined by the researcher. Recommended Positve Control (IHC): Acetone fixed human tonsil Recommended Negative Control: I1904-78R: IgG1 Murine Negative Control Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2549-27B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2: 269-274, 2. Sun, X. et al. (2003) Mouse B7-H3 induces antitumor immunity. Gene Ther. 10: 1728-1734, 3. Ma, L. et al. (2007) Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy. J. Hepatol. 46: 98-106.
Additional info: Recognizes human CD276.

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